A driver is on the run after allegedly accelerating a vehicle towards police officers who had approached her in Sydney's eastern suburbs, striking several cars in the process.

Officers had attempted to speak with the 32-year-old woman, who is understood to be wanted by police, when she allegedly drove the car in their direction before fleeing the scene.

The vehicle is reported to have collided with other cars during the incident. It is understood the woman remained at large following the confrontation.

Police are continuing their efforts to locate the wanted driver. Inquiries into the full circumstances of the incident are ongoing, and no further details about any injuries have been confirmed at this stage.